Abstract Search

ea0081p189 | Reproductive and Developmental Endocrinology | ECE2022

Is there a link between polycystic ovary syndrome and transgenerational transmission of a reproductive and metabolic function in male offspring?

Risal Sanjiv , Li Congru , Luo Qing , Fornes Romina , Manti Maria , Lu Haojiang , Eriksson Gustaw , Ohlsson Claes , Lindgren Eva , Crisosto Nicolas , Maliqueo Manuel , Echiburu Barbara , Recabarren Sergio , Sir Petermann Teresa , Benrick Anna , Brusselaers Nele , Qiao Jie , Deng Qiaolin , Stener-Victorin Elisabet

Our previous study showed that polycystic ovary syndrome (PCOS)-like reproductive and metabolic phenotypes induced by maternal dihydrotestosterone (DHT)-exposure, can be passed on in mice from mothers (F0) to daughters (F1), granddaughters (F2), and even to great-granddaughters (F3). The female transmission is independent of diet-induced obesity and is mediated by transcriptional and mitochondrial perturbations of oocytes accompany. ...

0 shares

Endocrine Abstracts

Is there a link between polycystic ovary syndrome and transgenerational transmission of a reproductive and metabolic function in male offspring?

BiosciAbstracts